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This protection is in effect for four years from the date of buy on all original rings purchased after July 1 1998 and is limited to a single substitute of your original high school ring during the four 12 months period. The periodic sequence of metallic elements with atomic numbers 89 to 103 from actinium Buffer definition is fellow man particularly an old man. The effect is quot Greater Concentration quot not Clarity and offers three mana tick for 20 minutes. This ring is a thin but sturdy piece of forged steel crafted to resemble a serpent swallowing its tail and is magically imbued to reveal the secrets and techniques of arcane mastery to its wearer. Item Drop Details The restrained condition doesn t prohibit any actions other than movement over distance so yes any spell may be solid while restrained. Material This item is made out of Gem Spell Storing Major As the minor ring of spell storing besides it holds up to ten levels of spells. Improved Stand Still Stand Still 4 bonus to melee attacks with Stand Still Improved Unarmed Strike Deal more damage and threaten squares with unarmed strikes In The warlock s Thief of Five Fates characteristic lets a warlock forged bane with a spell slot which means the spell is 1st degree or greater relying on the slot that the warlock expends to solid it. This allowed a spellcaster to The spell uses its regular Casting Time vary and Duration and the consumer of the item must concentrate if the spell requiresConcentration. Energized passive was educated 5 through the mages 39 wrath testing in addition to focus light armor pen and penetrating magic destro affecting passive. The ChloraPrep formulation is the one antiseptic formulation whose persistent anti microbial energy has been confirmed in research after scientific research. If the Water Element is efficiently extracted by the spell will probably be physically obtainable afterwards. To be readied a spell will need to have a casting time of 1 motion and holding onto the spell s magic requires concentration. Aether towers exist in some cities that increase the speed that airies absorb aether within the surrounding space. Get a pleasant field to house a ritual go package for if you need to journey to a friend s house or to the again yard. The bottles are filled with crystals herbs and magic and are topped off with a corresponding candle shade. At the Inner Circle Sanctuary group we ask our first year students to do a spell every moon part a waxing moon spell and a waning moon spell. However for many using a wand is a way of focusing of mentally balancing the forces. Take a black candle and place an image of thine enemy in front of thee and tilt the candle so the wax drips upon the would be victim within the picture. This spell pool Aug eleven 2020 Cloak of Concentration Rod of Healing Short Sword Spell Focus Warrior 39 s Bane Armored Cloak Heavy Mace Apprentice Staff Cursed Orb Dynasty Plate Helm Honed Edge Knight 39 s Shield Restored Artifact Spiked Shield Stone of Binding The mages of Air and Fire have a big probability to inflict a crucial damage to the enemy with magic the mages of Light and Shadow have a poisoning impact that can not be removed and the mages of Water and Earth are a lot weaker than these of different schools however heavyweights have a big likelihood to stun the opponent with magic and rating 2 hits in a row. You should purchase the nuggets from the Guild of Alchemists in Ankh Morpork or the House of Magic in Creel Springs. Find the right cleaning products and learn how to use bleach disinfecting wipes and other cleansing supplies to take away stains deep clear and sanitize. Category Clear Weapon Keep in thoughts that since the second spell isn t a bonus motion spell you don t have the second spell should be a cantrip restriction. For melee a full blast Armor nbsp Requires Attunement This ring stores spells cast into it holding them till the attuned wearer uses them. Alender attacks a Zhentarim agent carrying a go well with of chain armor a small defend and a ring of safety 1. From studying the book I assume any motion the could cause harm shoot hand to hand spell thrown rock or an impact that would make casting require too much focus would disrupt the particular person making an attempt to solid the spell and cause them to waste the spell slot and take 1 normal action. A quantitative measure of the power of an acid in answer expressed as an equilibrium fixed for a chemical dissociation response in the context of acid base reactions. Adventure Path If your highschool class ring is lost or stolen Balfour will substitute the ring. Ring rare requires attunement This ring stores spells cast into it holding them till the attuned wearer uses them. A spell cast from a ring of spell storing or a similar ioun stone casted pre combat inside it by you is completely the identical with your spell solely you don 39 t should spend an motion to cast it. The spell uses its regular casting time vary and period and the consumer of the item must focus if the spell requires concentration. ChloraPrep affected person preoperative skin preparation is a fast acting persistent and broad spectrum antiseptic for a wide range of procedures. These spells are created by forum members that are a part of the wizarding world however not canon In This Topic Spell Potion Creation Sheet You must full to get your spell permitted Rules about spells potions List of spells and potionsr.

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The various nbsp 1 Jul 2019 Children are high customers of antibiotics but very little progress has been made with creating paediatric antibiotic stewardship programmes. Main Entry an ti bi ot ic Pronunciation ant i b t ik an t ant i b Function noun a substance produced by an organism as a fungus or bacterium that in dilute resolution inhibits or kills a harmful microscopic plant or animal and especially one which causes disease Antibiotic resistance occurs when bacteria survive and proceed inflicting an infection despite therapy with an antibiotic the micro organism are not delicate to that antibiotic. Penicillin was the primary antibiotic used successfully in treating bacterial infections. A sort of drug that was officially found in 1928 Doctor You have strep throat so I might be prescribing you a ten day antibiotic. Meaning pronunciation image instance sentences grammar utilization notes synonyms and extra. Antibiotics solely work for bacterial infections and not for viral infections such because the frequent chilly flu or sore throat. Jan thirteen 2016 Antibiotics can have many unwanted effects as diarrhea The overuse of the antibiotics is the principle concern worldwide The overuse of the antibiotics contributes to the rise within the bacterial infections So The bacteria have gotten resistant to the antibacterial medications. Antibiotics An antibiotic is an agent that both kills or inhibits the growth of a microorganism. It was first produced within the late 1950s and was developed as a sort of antibiotic called a penicillinase resistant Definition of broad spectrum antibiotic within the Definitions. Selecting an antibiotic that may optimally deal with an an infection while minimizing antagonistic results and the event of resistance is just the first step as one should additionally consider the affected person s individual pharmacokinetic alterations and the pharmacodynamic properties of the drug when prescribing it as properly. However as with most drugs antibiotics can lead to side effects that may range from being a nuisance to critical or life An antibiotic is a substance used to kill micro organism. Mechanism of motion describes the biochemical process particularly at a molecular degree. However some antibiotics have been associated with a large extent of opposed unwanted side effects ranging from delicate to very severe depending on the type of antibiotic used the microbes targeted and the person patient. Though t What are some of the most commonly prescribed antibiotics View our record of the top generic and model drugs and be taught in regards to the kinds of antibiotics. Antimicrobial drugs have been widely utilized in human and veterinary medication for more than 50 years with tremendous benefits to both human and animal health. The preferred classification is the latter one which can be divided into major groups as follows a Chemotherapeutic brokers used to remedy infectious ailments and most cancers. In addition the rules will allow for the primary time an proprietor of an institution and an worker selling artificial drugs to be charged with possession of an illicit substance. The basic definition of an antibiotic is a compound produced by a microorganism that inhibits the growth of one other microorganism. Drug therapy pharmacotherapy is an important a part of the medical subject and relies on the science of pharmacology for continual development and on pharmacy for applicable administration. Overprescribing of antibiotics is a major problem worldwide as it results in antibiotic resistance when certain micro organism become immune to the results of antibiotics. Hepatic metabolism excretion is generally convenient as a result of this implies the drug dose doesn 39 t need to be adjusted based on renal function. What does broad spectrum antibiotic mean Information and translations of broad spectrum antibiotic in essentially the most comprehensive dictionary definitions resource on the internet. It is understood that worldwide more than 60 The global antibiotics market is anticipated to foresee vital growth over the forecast period. Also even if lab in vitro supports that appropriate antibiotic was prescribed it may not. A substance similar to The antibiotics that save one particular person 39 s life may result in antibiotic resistance that will hurt others. Dec 05 2018 Antibiotics are medication that are used within the remedy or prevention of bacterial infections. From semisynthetic antibiotic in A Dictionary of Genetics video sharing camera cellphone video phone free addContent Apr 22 2019 The first category of illicit drugs consists of those medication which are unlawful to manufacture sell buy and consume. Antibiotics are ineffective within the therapy of viruses similar to colds and circumstances of flu. It s difficult to distinguish a severe viral infection from a mild to average bacterial inf Experts are concerned concerning the development of people not finishing after which sharing their antibiotics. It is known that worldwide greater than 60 Antibiotics are used extensively in livestock production for management prevention and remedy of illness and for production purposes such as development promotion. The mechanism of motion of aspirin entails irreversible inhibition of the enzyme cyclooxygenase subsequently suppressing the production of prostaglandins and thromboxanes thus reducing ache and inflammation. Answer your medical questions on prescription drugs nutritional vitamins and Over the Counter medicines.

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Call your doctor in case you have any uncommon issues whereas receiving this treatment. If you still have symptoms of infection after you finish the chloramphenicol injection, speak to your physician. Chloramphenicol, a broad-spectrum antibiotic, has been used to deal with extreme infections for several decades. However, chloramphenicol confirmed good in vitro exercise in opposition to many vancomycin-resistant enterococcal infections and is useful for certain life-threatening infections (22, 30). Chloramphenicol increased the plasma drug concentrations or results of several medicine, such as cyclosporine, tacrolimus, and phenytoin (four, 10, 14, 17, 20, 25, 29, 32, 36, 38). A 25 mM chloramphenicol stock resolution was prepared by dissolving chloramphenicol in distilled water, and this resolution was serially diluted in distilled water. For each substrate (probe drug), preliminary experiments were performed to decide whether or not metabolite formation was linear with respect to incubation time and microsomal protein concentrations. Furthermore, a number of drug interactions between chloramphenicol and coadministered drugs have supported this hypothesis (four, 10, 14, 17, 20, 25, 29, 32, 36, 38). Moreover, when we incubated a racemate of warfarin with chloramphenicol in human liver microsomes, we discovered chloramphenicol inhibited R-warfarin metabolism, whereas S-warfarin was not inhibited (knowledge not proven). Roles of cytochrome P4502C9 and cytochrome P4502C19 within the stereoselective metabolism of phenytoin to its main metabolite. Nosocomial infections with vancomycin-resistant Enterococcus faecium in liver transplant recipients: threat factors for acquisition and mortality. Vancomycin-resistant enterococci: an emerging pathogen in immunosuppressed transplant recipients. Interaction between tacrolimus and chloramphenicol in a renal transplant recipient. Interindividual variations in human liver cytochrome P-450 enzymes concerned within the oxidation of medicine, carcinogens and poisonous chemical compounds: studies with liver microsomes of 30 Japanese and 30 Caucasians. Prediction of cyclosporine clearance in liver transplant recipients by the use of midazolam as a cytochrome P450 3A probe. Copyright, Purdue Research Foundation, 1996 | Chemotherapy Table of Contents | | Address | Chloramphenicol is a virtually good antibacterial with one major flaw -- the production of aplastic anemia and other blood dyscrasias in a small share of sufferers treated. This bacteriostatic antibiotic is efficient in a variety of infectious diseases and distributes uniformly all through the physique. As shown in the accompanying determine, it incorporates a nitrobenzene ring, an amide bond, and an alcohol operate. The nitrobenzene is related because it results in the formation of fragrant amines which can be carcinogenic. Chloramphenicol base has low water solubility and excessive lipid (in natural alcohols) solubility. It binds to the peptidyl transferase enzyme to inhibit switch of the growing polypeptide to the next amino acid occupying the "Acceptor" site. Resistance is because of deactivation of the drug by acetylation of the hydroxyl group, amidase hydrolysis of the amide group, or discount of the nitro group. Normally delicate organisms can turn out to be resistant by way of mutation (a sluggish, gradual process) or by transfer of resistance. In pigs fed 20 ppm of chloramphenicol for some time, sensitive coliforms had been changed by resistant ones. Because of the potential for growth of hypersensitivity, chloramphenicol ought to be used in topical purposes sparingly, paying particular consideration to protecting the individual administering the drug. Chloramphenicol is inappropriate to be used in animals meant for meals because of potential health hazards to shoppers. Liver (and bile), kidney (and urine), milk, and placentae all have high concentrations. In people, as much as ninety% is eliminated as the chloramphenicol glucuronide conjugate.

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The potency of tetracycline hydrochloride is lowered in solutions having a pH below 2. First, it reversibly epimerizes to four-epitetracycline which dehydrates irreversibly to four-epianhydrotetracycline after which reversibly to anhydrotetracycline or that tetracycline irreversibly dehydrates on to anhydrotetracycline, which reversibly epimerizes to four-epianhydrotetracycline. Although four-epianhydrotetracycline now serves as an essential standard for monitoring tetracycline stability, the degradation is related to a loss of antibiotic exercise and enhanced toxicity. The four-epianhydrotetracycline is taken into account biologically lively and is implicated in tetracycline toxicity. A research by Sigma-Aldrich[eight] shows that tetracycline stored for about 4 years under zero°C nonetheless displayed a single spot by skinny-layer chromatography. Pharmaceutical corporations, particularly these within the tropical regions, ought to be sure that raw materials and the completed merchandise are stored at low temperature whereas making certain dehumidified situation, gentle, and acidic/alkaline situations protection during filling of the capsules and different production processes. Tetracycline antibiotics: Mode of action, purposes, molecular biology, and epidemiology of bacterial resistance. Determination of tetracycline and its main degradation products by liquid chromatography with fluorescence detection. Jared Kushner and Ivanka Trump continued their stay along with his family in Long Branch, New Jersey, on Sunday [url=http://www. There are a number of locations all over the world famed for the [url=http://www. In the most recent Intersection we visited Chelsea during the Frieze Art Fair and spotted people who stated their type influences vary from their grandmothers to the avant-garde fashion firm Comme des Garons. The actress, 27, took to Instagram on Sunday night to announce the arrival of her daughter Nova, who she welcomed earlier this month along with her boyfriend of three years,Matthew, additionally 27. Some folks dont have credit or debit cards, so a rising variety of state and local governments are requiring companies to settle for cash. Professor Carl Heneghan, a former doctor and now Oxford University researcher, stated in Parliament’s Science and Technology Committee today that coughs at all times spike in September. Police will allege a man, forty three, sexually assaulted a girl and four children then aged between three and 16 – on multiple events between 1995 and 2012 in Sydney’s south-west. Italian newspaper La Repubblica cites an official statement from the Umbrian airport dated September 17 which says that Mr Johnson travelled through ‘in the previous few days. Denis Gurianov scored an influence-play goal in additional time of Game 5 to send the third-seeded Stars to the ultimate [url=https://debateuncensored. Researchers from the University of Queensland studied the placement of worldwide protected areas of land as well as the impression of human activity on these areas. Tibi is giving pandemic-period classes in private fashion, and finding new paths forward for its enterprise. The stylist, 40, from Toronto, made the claim in an Instagram post, three weeks aftershe deleted a throwback snap of one of her twin sons at Meghan Markle’s marriage ceremony. Hibiscus asada, vegetable trompos and nutty chorizos due to inventive cooks in Los Angeles, meatless tacos are thriving within the pandemic era. The announcement by the senator from Alaska probably complicates efforts to quickly fill the vacancy left by the death of Justice Ruth Bader Ginsburg. Yet the occasion was not fairly so straight ahead for Unorthodox’s Shira Haas, who was pressured to keep awake until four. The former vice chairman and the Democrats have been $187 million behind President Trump and the Republicans this spring. The Euphoria star, 24, took to Twitter to rejoice turning into the youngest thespian to win Outstanding Lead Actress in a Drama Series The San Francisco 49ers lost two stalwarts from their line of defense, their beginning quarterback and running again on Sunday. All those who are selected to be interviewed face-to-face will obtain $300 in money. The Australian Government processed one hundred forty,366 permanent arrivals final year, with Indians topping the listing at 26,000 citizens, followed by 18,587 from China. Rich folks don’t just have larger financial institution balances and more lavish life than the remainder of us — additionally they have bigger carbon footprints. Christies is hoping to break records with its sale of the dinosaur, nicknamed Stan, which might be on public view by way of Oct. The sequence, which debuted final year, depicts white supremacists, police brutality and rows over masks-sporting, making it a timely piece of theatre that faucets into the present zeitgeist of the U,S,A.

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Mortality charges were higher with advancing age and in patients with well being-care acquired infections. Add what-if eventualities here: If the urine tradition reveals yeast, assess for symptoms of urinary tract infection as a result of funguria most often represents asymptomatic colonization of the urinary tract (see “Are you positive your patient has pyelonephritis/sophisticated urinary tract infection? Urology consultation may be needed for removal of fungal balls or irrigation of the urinary system with an antifungal agent (amphotericin B). If a patient is systemically ill (fever, hypotension), present empiric broad spectrum antimicrobial remedy whereas evaluating the urinary tract with repeat cultures and imaging. If the urine tradition reveals two gram-negative rods in related portions, think about each probably pathogenic and supply antimicrobial remedy for each organisms. Perform blood cultures and consider analysis of the higher tract with imaging for pyelonephritis or renal abscess. How do you contract pyelonephritis/difficult urinary tract infection and the way frequent is this disease? In an observational study of girls with type 1 diabetes mellitus, the prevalence of cystitis was 15%, similar to the prevalence in a separate cohort of ladies without diabetes. The prevalence of pyelonephritis was three% in diabetics, higher than within the nondiabetic group. The premise is that close contact or ingestion of poultry (or different animals) with multidrug resistant gram-unfavorable flora might result in the acquisition of the micro organism by people. For example, a strain of Enterococcus faecalis was isolated from the urine of a patient who had close contact with poultry carrying the same clone. Klebsiella and Proteus may be extra common amongst hospitalized or instrumented patients. Other gram-negative rods, together with Serratia, Morganella, Citrobacter, Enterobacter, Acinetobacter, and Pseudomonas, are present in sufferers with previous well being care and antimicrobial exposure. However, the inflammatory response can be more extreme and disseminated infection with this live attenuated strain of Mycobacterium bovis can happen. Systemic involvement with fever, sepsis, prostatitis, hepatitis, and pneumonitis has been reported. Patients with candiduria and an indwelling catheter ought to have the catheter eliminated or changed, with a repeat urine culture from a recent catheter. If candiduria persists and there are local or systemic indicators of infection with out one other identifiable cause, antifungal therapy must be initiated. In each of those instances, antifungal remedy is warranted together with surgical administration (i. The presentation is often fever with particular cystitis symptoms and gross hematuria. Bacterial infection of the urinary tract is related to elevation of acute phase reactants, including C-reactive protein. What different scientific manifestations might help me to diagnose and handle pyelonephritis/complicated urinary tract infection? Additional diagnostics depend on the particular patient threat components and may require urologic session for cystoscopy and voiding studies for assessment for anatomical or useful abnormalities. Examination of the urethral meatus in males with cystitis signs ought to be carried out to detect a discharge that might point out urethritis. Likewise, in ladies with cystitis symptoms, a pelvic examination may be useful for ruling out vaginitis or cervicitis. The regimen of alternative has been ciprofloxacin; nevertheless, elevated resistance to ciprofloxacin has led to breakthrough episodes of sepsis and bacteremia. Optimal prophylaxis regimens apart from the fluoroquinolones are at present being evaluated but may be guided by local resistance data or by rectal cultures. Roxithromycin contains the identical 14-membered lactone ring as erythromycin, nevertheless, the ketone carbonyl group in erythromycin is replaced with an N-oxime side chain. The structure of roxithromycin is: Roxithromycin is sold under the commerce names Surlid, Rulide, Biaxsig, Roxar, and Roximycin and is commercially out there as a pill or oral suspension. Roxithromycin has an identical antimicrobial spectrum as erythromycin but is more practical against sure gram-negative bacteria, significantly Legionella pneumophlia.

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This has led to the evaluation of upper than usual doses of ivermectin in a phase 3 trial to assess the security. The results confirmed the drug was tolerated with the ten-fold dosing regime as well as at 60 mg three times a week. The researchers used a inhabitants model to examine the pharmacokinetics of the drug. This included the transit absorption, drug elimination, and weight of the patient. The model was primarily based on healthy individuals who took 12 mg ivermectin orally after meals. A hundred simulations of total and certain ivermectin were performed to observe the whole plasma focus-time profile. Different doses had been used, such because the accredited dose of 200 μg/kg, a hundred and twenty mg in a single weekly dose, and 60 mg three times per week (at 72-hour intervals, in healthy topics). These further simulations were carried out because of the observation that after a subcutaneous dose, ivermectin levels remained secure in cattle lungs for eight days. The focus-time graph for unbound plasma ivermectin was additionally predicted from the info. To attain this stage, ivermectin would wish to accumulate within the lungs greater than 25 instances the calculated price on the permitted weekly dose. With the seventy two-hourly dosing of 60 mg, it must rise to 5 times the observed degree. All over the world, ivermectin got here into widespread use of off-label in response to the news of the in vitro success in opposition to the virus. At a dose of a hundred and fifty μg/kg, remark of fifty two sufferers on mechanical ventilation appeared to present clinical profit with the drug in distinction to over 1,900 patients on conventional treatment. Though these outcomes have to be analyzed to rule out confounding components and biases, on the surface, they would seem to recommend that very low lung concentrations of ivermectin are capable of inhibit the virus. This may counsel that the lung distribution or accumulation of this drug is much higher in people than in cattle. In distinction, the concentrations of ivermectin reported inhibiting the coronavirus in vitro were markedly higher than those achieved in human lung or plasma with the permitted doses of ivermectin. As a result, say the researchers, “the chance of a successful medical trial using the permitted dose of ivermectin is low. Future suggestions The researchers advise a dose-response study utilizing a control group, in addition to testing the potential for inhaled ivermectin and combination therapy. The dose-response study should begin with the addition of potentiating compounds to cut back the brink of viral inhibition to the tune of 0. Inhaled ivermectin would permit for greater dosage and elevated local lung concentrations with out additional systemic publicity. Kaaki says urine is manufactured from principally water, but it additionally has salt (sodium, potassium and chloride), uric acid and urea. Uric acid is a pure waste product from meals digestion and urea is a waste product manufactured from ammonia and carbon dioxide—all substances the physique tries to do away with by way of urine. Whereas with dehydration, the concentration of ammonia goes to be greater and the scent could be stronger,” Dr. Kaaki says a lot of elements impact your capacity to stay hydrated, including dimension, weight, medical situations, kidney perform, every day exercise stage and warmth and humidity of the day. That means milk, tea, water, coffee, soda, juice and even water in the foods we eat. Foul-Smelling Urine: Food Asparagus is the primary meals linked to dangerous-smelling urine. If you’ve heard some people say their pee doesn’t smell after eating asparagus, Dr. When you eat the vegetable, you ingest the acid, which goes to your blood stream, kidneys and makes its approach to urine in your bladder.

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Snorre, 50 years: Clinical efficacy has been demonstrated in infections attributable to generally occuring pathogens together with Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Kliebsiella species, Haemophilus influenzae (beta-lactamase positive and unfavorable), Branhamella catarrhalis (beta- lactamase positive and adverse) and Enterobacter species.

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Hogar, 38 years: Compositions for subcutaneous injection, intramuscular injection, or intravenous administration can comprise sterile isotonic aqueous buffer.

Gancka, 30 years: Antibiotic usage in animal agriculture is complicated as antibiotics are used not only for There are main information and data gaps on therapeutic purposes, but also for the prevention the usage of antibiotics in agricultural manufacturing of infectious ailments and to promote animal and on the development and unfold of resistance.

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References

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• Sugimura Y, Cunha GR, Bigsby RM: Androgenic induction of DNA synthesis in prostatic glands induced in the urothelium of testicular feminized (Tfm/Y) mice, Prostate 9(3):217n225, 1986. Sugimura Y, Cunha GR, Donjacour AA: Morphological and histological study of castration-induced degeneration and androgen-induced regeneration in the mouse prostate, Biol Reprod 34(5):973n983, 1986. Susset JG, Picker P, Kretz M, et al: Critical evaluation of uroflowmeters and analysis of normal curves, J Urol 109(5):874n878, 1973.
• Kumagi T, Akbar SM, Horiike N, et al. Administration of dendritic cells in cancer nodules in hepatocellular carcinoma. Oncol Rep. 2005;14:969-973.
• Elkayam U. Pregnancy and cardiovascular disease. In Braunwald E editor. Heart disease: a textbook of cardiovascular medicine. Philadelphia, 1992, WB Saunders, pp 1790-1809.